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Cysteine-, Methionine- and Seleno-Cysteine-Proline Chimeras: Synthesis and Their Use in Peptidomimetics Design

[ Vol. 12 , Issue. 3 ]

Author(s):

Azzurra Stefanucci, Roberto Costante, Giorgia Macedonio, Szabolcs Dvoracsko and Adriano Mollica   Pages 200 - 206 ( 7 )

Abstract:


Natural sulphurated amino acids are cysteine and methionine. Their importance in biological processes is largely known. Cysteine, plays a key role due to the thiol group, which represents a nucleophilic and easily oxidizable function. Synthetic methodologies to obtain Cysteine-, Methionineand Seleno-Cysteine-Proline chimeras are strongly desirable and particularly appealing in the field of organic chemistry.

Keywords:

Cysteine, methionine, seleno-cysteine proline chimeras, peptidomimetic design, χ-Space, chemical ligation.

Affiliation:

Dipartimento di Farmacia, Università di Chieti-Pescara “G. d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy.

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