Azzurra Stefanucci, Roberto Costante, Giorgia Macedonio, Szabolcs Dvoracsko and Adriano Mollica Pages 200 - 206 ( 7 )
Natural sulphurated amino acids are cysteine and methionine. Their importance in biological processes is largely known. Cysteine, plays a key role due to the thiol group, which represents a nucleophilic and easily oxidizable function. Synthetic methodologies to obtain Cysteine-, Methionineand Seleno-Cysteine-Proline chimeras are strongly desirable and particularly appealing in the field of organic chemistry.
Cysteine, methionine, seleno-cysteine proline chimeras, peptidomimetic design, χ-Space, chemical ligation.
Dipartimento di Farmacia, Università di Chieti-Pescara “G. d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy.