Submit Manuscript  

Article Details


Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L.

[ Vol. 13 , Issue. 4 ]

Author(s):

Soumia Bouzidi, Naima Benkiki, Messaoud Hachemi and Hamada Haba*   Pages 340 - 346 ( 7 )

Abstract:


Objective: This study was accomplished to evaluate the in vitro antioxidant activity, in vivo antipyretic and the anti-inflammatory activities of the n-butanol extract of roots and aerial parts of Algerian Eryngium campestre L.

Materials and Methods: The antioxidant properties were tested using DPPH radical scavenging and β- Carotene linoleic acid of various extracts from roots and aerial parts of E. campestre L., total phenolic and flavonoid contents were also determined. Furthermore, the anti-inflammatory and antipyretic activities of the n-butanol extracts were investigated on female wistar rats at the dose levels of 250 and 500 mg/kg body weight, using the egg albumin induced oedema and brewer’s yeast induced pyrexia method respectively.

Results: n-butanol extract of aerial parts had considerably higher antiradical activity with IC50 value of 16.140 µg/ml, and a good anti-inflammatory activity comparable to the standard drug diclofenac. Also, the n-butanol extract of roots possessed a better antipyretic effect (at both dose 250 mg/kg and 500 mg/kg) compared to the n-butanol extract of aerial parts.

Conclusion: These results suggested that Eryngium campestre L. could be used to treat various inflammatory diseases.

Keywords:

Eryngium campestre, inflammation, pyrexia, antipyretic activity, anti-inflammatory activity, apiaceae, antioxidant activity.

Affiliation:

Laboratory of Biotechnology of Bioactive Molecules and Cell Pathophysiology, Faculty of Nature, and Life Sciences, Batna-2 University, Batna, Laboratory of Biotechnology of Bioactive Molecules and Cell Pathophysiology, Faculty of Nature, and Life Sciences, Batna-2 University, Batna, Laboratory of Biotechnology of Bioactive Molecules and Cell Pathophysiology, Faculty of Nature, and Life Sciences, Batna-2 University, Batna, Faculty of Matter Sciences, Department of Chemistry, Laboratory of Chemistry and Environmental Chemistry (L.C.C.E), Batna-1 University, Batna

Graphical Abstract:



Read Full-Text article