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Synthesis of Some Novel Substituted Phenyl β, β-Diphenyl Propanoate with Analgesic and Anti-inflammatory Activity

[ Vol. 14 , Issue. 1 ]

Author(s):

Harshita Dhall, Arvind Kumar and Arun K. Mishra*   Pages 26 - 32 ( 7 )

Abstract:


Background: In the present study, a series of substituted phenyl β,β-diphenylpropanoate were synthesized by the reaction of β,β-diphenylpropionyl chloride with various substituted phenols in acetone.

Methods: Upon synthesis of compounds, the characterization of synthesized compounds was made using IR, NMR, Mass spectroscopy and elemental anaysis. These derivatives were screened for analgesic activity and anti-inflammatory activity (Carrageen induced paw edema method) Diclofenac sodium and Indomethacin were used as standard drug for analgesic activity and anti-inflammatory response, respectively.

Results: The compounds 2-nitro Phenyl 3,3 diphenyl propionate (HD-5) and 4-nitro Phenyl 3,3 diphenyl propionate (HD-2) exhibited significantlly potent anti-inflammatory and analgesic activity (two to three times) when comparision was made with control group. The response of promising compound (HD-5) for analgesic and anti-inflammatory action was highest among all the test compound and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).

Conclusion: The findings of present work confirm the potent action of HD-5 compounds as analgesic and anti-pyretic in experimental animals.

Keywords:

Aryl propionic acid, analgesic activity, anti-inflammatory activity, ulceration, potency, biosynthesis.

Affiliation:

Drug Design Laboratory, School of Pharmaceutical Sciences, IFTM University, Moradabad 244001, Uttar Pradesh, Drug Design Laboratory, School of Pharmaceutical Sciences, IFTM University, Moradabad 244001, Uttar Pradesh, Drug Design Laboratory, School of Pharmaceutical Sciences, IFTM University, Moradabad 244001, Uttar Pradesh

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