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Neoflavonoids as Prospective Compounds Against Parasitic Neglected Tropical Infections and Human Immunodeficiency Virus

[ Vol. 13 , Issue. 4 ]

Author(s):

Gláucio B. Saldanha, George L.S. Oliveira, José C.C.L. da Silva, Maria C.P. Oliveira, Ana P.S.C.L. da Silva and Juceni P. de Lima David   Pages 276 - 291 ( 16 )

Abstract:


Background: Neoflavonoids comprise a group of compounds that have a C6-C3-C6 carbon skeleton and that naturally occur in higher plants from families Clusiaceae, Leguminosae, Rubiaceae, Passifloraceae, Asteraceae and Rutaceae.

Objective: Neoflavonoids have drawn great interest lately due to their pharmacological and biochemical properties found in vitro and in vivo studies, which is attributed to the pattern of substitutions found in their basic chemical structure.

Methods: This review was prepared by analyzing articles selected from Science Direct, Scopus, Pub Med, Web of Science and SciFinder.

Results: Among other pharmacological activities, in vitro and in vivo studies have highlighted these compounds as promising bioactive molecules in the treatment of some parasitic neglected tropical infections (NTIs) such as malaria, leishmaniasis and American trypanosomiasis (Chagas Disease). Neoflavonoids have also showed activity against HIV-1 (human immunodeficiency virus type 1), and have been used to develop new molecules for the treatment of HIV/AIDS.

Conclusion: Therefore, a more intensive research of neoflavonoids can provide inputs to discover and develop alternative therapies from new bioactive molecules. Thus, this review summarizes the results of studies involving neoflavonoids and their derivatives with therapeutic implications in the treatment of NTIs and HIV.

Keywords:

American trypanosomiasis, bioactive molecules, leishmaniasis, malaria, neoflavonoids, infections, chagas disease.

Affiliation:

Institute of Chemistry, Federal University of Bahia, Salvador 40170-280, BA, Department of Pharmacy, Post- Graduation Program in Biotechnology, Research Laboratory in Experimental Neurochemistry, Federal University of Piauí, Teresina 64049-550, Piauí, Department of Pharmacy, Post- Graduation Program in Biotechnology, Research Laboratory in Experimental Neurochemistry, Federal University of Piauí, Teresina 64049-550, Piauí, Department of Biology, Federal University of Piauí, Teresina 64049-550, Piaui, Department de Bioquimica e Farmacologia, Federal University of Piaui-UFPI, Campus Universitário Ministro Petrônio Portella, Post-Graduation Program in Biotechnology, Ininga, Teresina, Piaui, CEP: 64048-901, Institute of Chemistry, Federal University of Bahia, Salvador 40170-280, BA

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