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Synthesis of 2-(Bis (2-Chloroethyl)Amino)-N-(5-Substitutedphenyl)- 1,3,4- Thiadiazol-2-Yl)Acetohydrazide And Evaluation of Anticancer Activity

[ Vol. 14 , Issue. 3 ]

Author(s):

Byran Gowramma*, Thaggikuppe K. Praveen, Subramanian Gomathy, Rajagopal Kalirajan, Baswan Babu and Nagappan Krishnavenic   Pages 309 - 316 ( 8 )

Abstract:


Objective: The objective of this study was to synthesize a series of 1,3,4-thiadiazole derivative and evaluate their possible in vitro and in vivo anticancer activity.

Method: Compounds 7a-f have been synthesized by chlorination of 2-[bis(2-hydroxyethyl)amino]-N-[5- substituted phenyl)-1,3,4-thiadiazol-2-yl]acetohydrazide with phosphorous oxychloride and phosphorous pentachloride. Synthesis of the targeted compounds was (7a-f) confirmed through their MP, IR, 1HNMR and mass spectrum studies.

Results: Compounds 7a and 7d showed considerable anticancer activity against Hep-2 cell lines and, therefore, selected for the in vitro studies and DLA cell line for the in vivo studies.

Conclusion: It may be concluded that the presence of nitro and chloro phenyl substituted 1,3,4- thiadiazoles showed significant anticancer activity.

Keywords:

Anticancer activity, 1, 3, 4-thiadiazole, daltons lymphoma ascites (DLA) cell line, 5-flurouracil, in vitro and in vivo screening.

Affiliation:

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, Mysore, Udhagamandalam 643001, Tamil Nadu, Department of Pharmacology, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, Mysore, Udhagamandalam 643001, Tamil Nadu, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, Mysore, Udhagamandalam 643001, Tamil Nadu, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, Mysore, Udhagamandalam 643001, Tamil Nadu, Department of Pharmaceutical Analysis, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, Mysore, Udhagamandalam 643001, Tamil Nadu, Department of Pharmaceutical Analysis, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, Mysore, Udhagamandalam 643001, Tamil Nadu

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