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Biopolymer Catalysed Synthesis of 6-methyl-4-phenylcarbamoyl-1, 2, 3, 4- Tetrahydropyrimidine-2-ones and Evaluation of their Anti-bacterial and Anti-tubercular Activities

[ Vol. 15 , Issue. 4 ]

Author(s):

Vasant Chabukswar*, Digamber Pawar, Kalpana Handore, Suresh Shisodia, Balasaheb Diwate, Pravin Adhav, Swati Jagdale, Anuruddha Chabukswar, Vishwas Gaikwad and Sabrina Dallavalle   Pages 408 - 414 ( 7 )

Abstract:


An efficient one-pot biocatalysed ultrasound assisted synthesis of dihydropyrimidinones/ thiones has been developed under solvent free conditions. The use of biodegradable, non toxic, agar-powder as a catalyst provide advantages like high yield, simple operation, mild reaction condition with short reaction time. 1,2,3,4-tetrahydropyrimidine-2-ones/thiones formed were characterized by mass and 1H NMR spectroscopy. The dihydropyrimidinones substituted with electron donating groups like fluorine, hydroxy along with thienyl groups exhibited good antibacterial activity. The compounds exhibited favorable binding interactions with mycobacterium target protein H37Rv. 4-methoxy substituted dihydropyrimidinones derivative showed significant anti-tuberculosis activity.

Keywords:

Biocatalysed synthesis, solvent free, green chemistry, antibacterial activity, anti tubercular activity.

Affiliation:

Department of Chemistry, Ness Wadia Nanoscience Research Center, Nowrosjee Wadia College, (S. P. Pune University), 19, Joag Path, Pune -411001, Department of Chemistry, Ness Wadia Nanoscience Research Center, Nowrosjee Wadia College, (S. P. Pune University), 19, Joag Path, Pune -411001, Department of Chemistry, Ness Wadia Nanoscience Research Center, Nowrosjee Wadia College, (S. P. Pune University), 19, Joag Path, Pune -411001, Department of Chemistry, Ness Wadia Nanoscience Research Center, Nowrosjee Wadia College, (S. P. Pune University), 19, Joag Path, Pune -411001, Department of Chemistry, Ness Wadia Nanoscience Research Center, Nowrosjee Wadia College, (S. P. Pune University), 19, Joag Path, Pune -411001, Department of Chemistry, Ness Wadia Nanoscience Research Center, Nowrosjee Wadia College, (S. P. Pune University), 19, Joag Path, Pune -411001, MAEER’s Maharashtra Institute of Pharmacy, Kothrud, Pune - 411038, MAEER’s Maharashtra Institute of Pharmacy, Kothrud, Pune - 411038, Department of Chemistry, K.T.H.M college Nashik, DeFENS, Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Milano, Via Celoria, 20133 Milano



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