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Thymol Chemistry: A Medicinal Toolbox

[ Vol. 15 , Issue. 5 ]

Author(s):

Jyoti, Divya Dheer, Davinder Singh, Gulshan Kumar, Manvika Karnatak, Suresh Chandra, Ved Prakash Verma and Ravi Shankar*   Pages 456 - 475 ( 20 )

Abstract:


Background: Thymol is a natural phenolic monoterpenoid widely used in pharmaceutical and food preservative applications. Thymol isomeric with carvacrol, extracted primarily from Thymus species (Trachyspermum ammi) and other plants sources such as Baccharisgrise bachii and Centipeda minima, has ethnopharmacological characteristics.

Methods: This review was prepared by analyzing articles published on thymol moiety in last decade and selected from Science Direct, Scopus, Pub Med, Web of Science and SciFinder. The selected articles are classified and gives brief introduction about thymol and its isolation, illustrates its natural as well as synthetic sources, and also therapeutic benefits of thymol worldwide

Results: Thymol has been covering different endeavors such as antimicrobial, antioxidant, antiinflammatory, antibacterial, antifungal, antidiarrhoeal, anthelmintic, analgesic, digestive, abortifacient, antihypertensive, spermicidal, depigmenting, antileishmanial, anticholinesterase, insecticidal and many others. This phenolic compound is among the essential scaffolds for medicinal chemists to synthesize more bio-active molecules by further derivatization of the thymol moiety

Conclusion: Thymol is an interesting scaffold due to its different activities and derivatization of thymol is proved to enhance its biological activities. However, more robust, randomised, controlled clinical trials would be desirable with well-characterised thymol preparations to corroborate its beneficial effects in diseased patients. Moreover, in view of the potential use of thymol and thymol-rich essential oils in the treatment of human infections, comprehensive studies on chronic and acute toxicity and also teratogenicity are to be recommended.

Keywords:

GC-MS analysis, carvacrol, thymol, Thymus species, monoterpene, carvacrol.

Affiliation:

Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, Department of Chemistry, Banasthali University, Banasthali, Rajasthan 304022, Genetics Resources & Agrotechnology Division, CSIR-IIIM, Jammu 180001, Department of Chemistry, Banasthali University, Banasthali, Rajasthan 304022, Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001



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