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Cannabis sativa L. Constituents and Their Role in Neuroinflammation

[ Vol. 15 , Issue. 2 ]

Author(s):

Vittoria Borgonetti, Paolo Governa*, Monica Montopoli and Marco Biagi   Pages 147 - 158 ( 12 )

Abstract:


The interest in Cannabis sativa L. phytocomplex as a medicinal tool is a recently-emerging topic. Neurodegenerative diseases represent a promising field of application for cannabis and its preparations, as most of this pathologic conditions relies on an inflammatory etiology. Several cannabis constituents display anti-inflammatory effects targeting multiple pathways. In this review, a comprehensive overview of the available literature on C. sativa constituents activities in neuroinflammation is given. On the basis that the anti-inflammatory activity of cannabis is not attributable to only a single constituent, we discuss the possible advantages of administering the whole phytocomplex in order to fully exploit the “entourage effect” in neuroinflammatory-related conditions.

Keywords:

Cannabis sativa L., neuroinflammation, cannabinoids, caryophyllene, apigenin, microglia, endocannabinoid system, phytotherapy.

Affiliation:

SIFITLab, Via Laterina 8, 53100 Siena, SIFITLab, Via Laterina 8, 53100 Siena, SIFITLab, Via Laterina 8, 53100 Siena, SIFITLab, Via Laterina 8, 53100 Siena

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