Submit Manuscript  

Article Details


Marine Streptomyces sp. VITASP as a Source of New Bioactive Secondary Metabolites

Author(s):

Aditi Thosar, Pooja Satpathy, Jemimah S. Naine and C. Subatha Devi*   Pages 1 - 7 ( 7 )

Abstract:


Background: The main aim of the study was to evaluate the bioactive properties of ethyl acetate crude extract of Streptomyces sp. VITASP with a view to assess their therapeutic potential.

Methods: The morphological, physiological and the biochemical properties of the strain Streptomyces sp. VITASP were confirmed by conventional methods. The present study evaluated the antibacterial, antioxidant and cytotoxic activities.

Results: The isolate was identified to be Streptomyces sp. (Genbank accession number: KR233807). The ethyl acetate extract of Streptomyces sp. VITASP showed maximum antibacterial activity of two Gram- positive and Gram- negative bacteria at 0.5mg/mL. The antioxidant potential of the crude extract exhibited strong reducing power activity at 0.5 mg/mL with 93±0.05% inhibition. The antiinflammatory and anti-diabetic properties were identified at 0.5 mg/mL concentration. The cytotoxic effect was found with an IC50 of 500

Keywords:

Marine Streptomyces, metabolites, bioactivity.

Affiliation:

VIT University, Biotechnology, VIT University, Biotechnology, VIT University, Biotechnology, Department of Biotechnology, School of Biosciences and Technology, VIT University



Read Full-Text article