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Marine Streptomyces sp. VITASP as a Source of New Bioactive Secondary Metabolites


Aditi Thosar, Pooja Satpathy, Jemimah S. Naine and C. Subatha Devi*   Pages 1 - 7 ( 7 )


Background: The main aim of the study was to evaluate the bioactive properties of ethyl acetate crude extract of Streptomyces sp. VITASP with a view to assess their therapeutic potential.

Methods: The morphological, physiological and the biochemical properties of the strain Streptomyces sp. VITASP were confirmed by conventional methods. The present study evaluated the antibacterial, antioxidant and cytotoxic activities.

Results: The isolate was identified to be Streptomyces sp. (Genbank accession number: KR233807). The ethyl acetate extract of Streptomyces sp. VITASP showed maximum antibacterial activity of two Gram- positive and Gram- negative bacteria at 0.5mg/mL. The antioxidant potential of the crude extract exhibited strong reducing power activity at 0.5 mg/mL with 93±0.05% inhibition. The antiinflammatory and anti-diabetic properties were identified at 0.5 mg/mL concentration. The cytotoxic effect was found with an IC50 of 500


Marine Streptomyces, metabolites, bioactivity.


VIT University, Biotechnology, VIT University, Biotechnology, VIT University, Biotechnology, Department of Biotechnology, School of Biosciences and Technology, VIT University

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