Kayla Spencer-Bakes and Ian Macreadie* Pages 692 - 695 ( 4 )
Background: Fluoxetine is a widely prescribed antidepressant that has associated antifungal activity.
Methods: This study examined the growth inhibitory and cytotoxic effects of fluoxetine on Candida glabrata.
Results: Fluoxetine inhibited growth of C. glabrata on media containing glucose as a carbon source: the inhibition was much greater when ethanol was the carbon source. In hypoosmotic conditions fluoxetine caused death of C. glabrata in one hour.
Conclusion: Fluoxetine inhibits fermentative and mitochondrial function of C. glabrata. It rapidly kills C. glabrata in hypoosmotic conditions.
Candida glabrata, fluoxetine, selective serotonin reuptake inhibitor, antifungal.
School of Science, RMIT University, Melbourne, School of Science, RMIT University, Melbourne