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Fluoxetine Inhibits Respiratory Growth of Candida glabrata and has Cytocidal Activity

[ Vol. 15 , Issue. 6 ]

Author(s):

Kayla Spencer-Bakes and Ian Macreadie*   Pages 692 - 695 ( 4 )

Abstract:


Background: Fluoxetine is a widely prescribed antidepressant that has associated antifungal activity.

Methods: This study examined the growth inhibitory and cytotoxic effects of fluoxetine on Candida glabrata.

Results: Fluoxetine inhibited growth of C. glabrata on media containing glucose as a carbon source: the inhibition was much greater when ethanol was the carbon source. In hypoosmotic conditions fluoxetine caused death of C. glabrata in one hour.

Conclusion: Fluoxetine inhibits fermentative and mitochondrial function of C. glabrata. It rapidly kills C. glabrata in hypoosmotic conditions.

Keywords:

Candida glabrata, fluoxetine, selective serotonin reuptake inhibitor, antifungal.

Affiliation:

School of Science, RMIT University, Melbourne, School of Science, RMIT University, Melbourne

Graphical Abstract:



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