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Secoiridoid Amarogentin from ‘Gentianaceae’ with their Health Promotion, Disease Prevention and Modern Analytical Aspects

[ Vol. 16 , Issue. 3 ]

Author(s):

Kanika Patel and Dinesh K. Patel*   Pages 191 - 200 ( 10 )

Abstract:


Background: Plant-based products and their derivatives have been widely used in the medi-cine, nutraceuticals, and the cosmetic and pharmaceutical field for a very long time. A large number of important drugs of modern medicine have also been derived from the plant's sources. Plant products specifically the pure phytochemical also known as ‘biomarkers’ have been used in the food and phar-maceutical industries. Biomarker compounds are pure phytochemical and they are mainly responsible for various pharmacological activities of plant material and examples of biomarker are Amarogentin, Vasicine, Hyoscyamine and Paclitaxel.

Methods: Various literature databases were searched to collect important information about Amarogen-tin in this review. Ethnomedicinal uses, pharmacological activities, phytochemical aspects and modern analytical tools of amarogentin were presented and discussed. Further, all the collected information’s were categorized into different section as per the need of the manuscripts. Moreover, data were also presented in the graphical abstract, Figures and Table section too.

Results: Swertia chirata (S. chirata)is a common plant of Gentianaecae family which is mainly known for their bitter taste. Gentiopicroside, amarogentin, swertiamarin, isovitexin and isogentisin are someimportant phytoconstituents of S. chirata. Decoction, infusion, pastes and juice of S. chirata are basi-cally used in the medicine. Various Pharmacological activities such as hypoglycemic, antimicrobial, antimalarial, antihepatotoxic, anticarcinogenic, antioxidative and anti-inflammatory have been reported in the literature for S. chirata plant. Amarogentin, a bitter secoiridoid glycoside of S. chirata has been well known for antibacterial, anticholinergic anti-lieshmanial, chemopreventive, antihepatitisand anti-cancer activities.

Conclusion: Information provided in the present paper regarding phytochemistry, pharmacological uses and analytical aspects including bioavailability will be beneficial to various disciplines of biological science. Development of plant tissue culture-based approaches is also needed for the proper conserva-tion of S.chirayita plants in the future

Keywords:

Amarogentin, analytical aspects, medicinal uses, pharmacological activities, S. chirayita

Affiliation:

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences (SIHAS), Sam Higginbottom University of Agriculture,Technology and Sciences, Allahabad, 211007, Uttar Pradesh, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences (SIHAS), Sam Higginbottom University of Agriculture,Technology and Sciences, Allahabad, 211007, Uttar Pradesh



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