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Bioactive Polyphenols as Promising Natural Medicinal Agents Against Cancer: The Emerging Trends and Prospective Goals

Author(s):

Om Prakash*, Shazia Usmani*, Amresh Gupta, Ruchi Singh, Namrata Singh and Akash Ved   Pages 1 - 20 ( 20 )

Abstract:


Background: There is much epidemiological evidence that fruits, vegetables, medicinal plants, and their phytochemicals could lower the progression and development of various forms of cancer. The plants are active reservoirs for novel chemical entities and provide a promising resource for the management of cancer. Methods: Several analyses have signified that bioactive flavonoids and phenolic acids might be widely practiced for the management as well as therapy of numerous carcinomas. A large number of research works are now focusing on natural polyphenolic compounds and trying to find out new and more effective treatment strategies for cancer patients. Results: The probable mechanism comprises anti-oxidant, anti-inflammation, apoptosis and induces inhibition of cell proliferation along with genomic phenomena elaborated in cancer therapy. Conclusion: In the last five years, studies investigated the antitumor potential of common polyphenolic groups (phenolic acids, flavonoids, lignins, resveratrol, stilbene, quercetin etc.) exploring the prospective mechanism, based on epidemiological data thus reporting therapeutic evidence and various clinical examinations.

Keywords:

anticancer, polyphenols, flavonoids, apoptosis, antioxidant, anti-inflammation

Affiliation:

Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh, Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh



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