Thorsten U. Meyer* Pages 394 - 406 ( 13 )
Background: Nitric oxide (NO) is known for decades to play a crucial role in many physio-logical processes: this includes acting as an anti-microbial mediator/agent, vasodilator, inhibitor of platelet aggregation, immune modulator, and tissue regeneration via regulation of epidermal cell migra-tion, collagen deposition and cytokine/chemokine microenvironment, making it a key player in wound healing.Methods: In order to demonstrate the therapeutic benefits as well as the safety of a NO wound irrigation solution, a broad literature review summarizing efficacy and safety data was conducted. Results: Beneficial effects on wound healing have been demonstrated in several non-clinical and clini-cal studies. The combination of NO and wound rinsing seems to be a promising approach in terms of improved wound healing of chronic wounds. Conclusion: Based on the results, no safety concerns are expected for a daily 15 minutes use of a NO-generating rinsing solution system for wound irrigation of diabetic foot ulcers in adults.
Nitric oxide, chronic wound, treatment, efficacy, toxicity, diabetic foot ulcer.
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