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Quinazolin-4-One: A Varsatile Molecule


Rakesh Amrutkar*, Sunil Amrutkar and Mahendrasing Ranawat   Pages 1 - 12 ( 12 )


Background: Quinazolines and quinazolinones constitute a major class of biologically active molecules both from natural and synthetic sources. We will limit this review to compounds possessing the 4(3H)-quinazolinone skeleton, which is found in compounds displaying significant biological and pharmacological properties. The molecular design of potential lead compound is still a key line of approach for the discovery and development of new chemical entities. A combination of two or more chemical moieties into one is a common approach of operation and this can most likely result in the improvement of pharmacological activity and removal of unwanted side effects.

Methods: We undertake search for peer-reviewed and research literature on quinazolinone moiety using different tools of literature survey. The quality of superior papers was assessed using standard tools. The distinctiveness of screened papers was that they were short and of high-quality content was reorganized and written in their own language

Results: The review will be expressed in two main sections, the first section will be related to synthetic procedures and the second section includes the biological importance of Quinazoline derivatives. Total hundred (100) to one hundred and ten (110) research papers ware searched. Out of these, seventy-eight papers were included in the review, the majority of research papers were from international journals. Fifty fours papers defined the different synthetic schemes considering the general strategies using orthosubstituted anilines such as 2-aminobenzoic acid (anthranilic acid) and its analogues, or isatoic anhydride as starting materials, which are condensed with acid chlorides, imidates or aldehydes. Microwave irradiation was also proven to be very useful to improve the yields, and in particular, it has been successfully applied to the Niementowski procedure involving the fusion of anthranilic acid with formamide. The remaining part of the review focuses on biological importance of the 4(3H)-quinazolinone scaffold as therapeutic agents and a broad range of activities like antibacterial, antifungal, antiviral, anticonvulsant, antitumor, antihypertensive, analgesic and anti-inflammatory agents has been highlighted.

Conclusion: The present review focuses on simplified, efficient and widespread literature of the methods of synthesis and diverse pharmacological activities of quinazoline and its derivatives have been highlighted.


Quinazoline-4-one, Pharmacophores, Discovery


Department of Pharmaceutical Chemistry, MGV`S Samjshri Prashantdada Hiray College of Pharmacy, Department of Pharmaceutical Chemistry, Sir Dr. M.S. Gosavi College of Pharmaceutical Education and Research, Nasik, Department of Pharmaceutical Chemistry, B.N. College of Pharmacy, Udaipur, Rajasthan

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