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Synthesis, Characterization, and Biological Evaluation of Novel Naringenin Derivatives as Anticancer Agents

[ Vol. 16 , Issue. 4 ]

Author(s):

Yogesh Murti* and Pradeep Mishra   Pages 442 - 448 ( 7 )

Abstract:


Background: In the present study, a series of substituted naringenin derivatives was synthe-sized by Claisen–Schmidt reaction using grinding technique.

Methods: Synthesized compounds were characterized on the basis of Fourier-Transform Infrared Spec-troscopy (FTIR), proton Nuclear Magnetic Resonance (1H NMR), Mass Spectroscopy (MS) and ele-mental analysis. These derivatives were screened for anticancer activity on breast (MCF-7) and colon (HT-29) cell lines using Sulforhodamine B (SRB) colorimetric assay.

Results: Results displayed improved inhibitory concentration (IC50) values of naringenin derivatives. IC50 values of 3(4-chlorobenzylidene)-5,7-dihydroxy-2(4-hydroxyphenyl)chroman-4-one are 10.35 μM (MCF-7) & 12.03 μM (HT-29), which is most potent compound in the series. These finding confirms the suitability of 3-substituted naringenin in improving the anticancer effect

Conclusion: Due to the intense interest in the development of drugs capable of inhibiting cancerous cells, naringenin derivatives may represent important precursor molecules for the therapeutic armamen-tarium of colon and breast cancer. Further structural modification in these structures will be of interest and may result in compounds having a better anticancer activity

Keywords:

Claisen-schmidt reaction, grinding technique, naringenin, colon cancer, breast cancer, immunomodulator.

Affiliation:

Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, N.H.#2 Delhi Mathura Road, Mathura-281406, Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, N.H.#2 Delhi Mathura Road, Mathura-281406



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