Yogesh Murti* and Pradeep Mishra Pages 442 - 448 ( 7 )
Background: In the present study, a series of substituted naringenin derivatives was synthe-sized by Claisen–Schmidt reaction using grinding technique.
Methods: Synthesized compounds were characterized on the basis of Fourier-Transform Infrared Spec-troscopy (FTIR), proton Nuclear Magnetic Resonance (1H NMR), Mass Spectroscopy (MS) and ele-mental analysis. These derivatives were screened for anticancer activity on breast (MCF-7) and colon (HT-29) cell lines using Sulforhodamine B (SRB) colorimetric assay.
Results: Results displayed improved inhibitory concentration (IC50) values of naringenin derivatives. IC50 values of 3(4-chlorobenzylidene)-5,7-dihydroxy-2(4-hydroxyphenyl)chroman-4-one are 10.35 μM (MCF-7) & 12.03 μM (HT-29), which is most potent compound in the series. These finding confirms the suitability of 3-substituted naringenin in improving the anticancer effect
Conclusion: Due to the intense interest in the development of drugs capable of inhibiting cancerous cells, naringenin derivatives may represent important precursor molecules for the therapeutic armamen-tarium of colon and breast cancer. Further structural modification in these structures will be of interest and may result in compounds having a better anticancer activity
Claisen-schmidt reaction, grinding technique, naringenin, colon cancer, breast cancer, immunomodulator.
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, N.H.#2 Delhi Mathura Road, Mathura-281406, Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, N.H.#2 Delhi Mathura Road, Mathura-281406