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Chemical Variability of Atractylis gummifera Essential Oils at Three Developmental Stages and Investigation of Their Antioxidant, Antifungal and Insecticidal Activities

Author(s):

Kenza Mejdoub, Imane Rihab Mami, Rania Belabbes, Mohammed El Amine Dib*, Nassim Djabou, Boufeldja Tabti, Nassira Gaouar Benyelles, Jean Costa and Alain Muselli   Pages 1 - 9 ( 9 )

Abstract:


Background: Atractylis gummifera is a cosmopolitan species that is particularly abundant in the Mediterranean regions. It has been used to treat many diseases, including intestinal parasites, ulcers, snakebite poisoning, hydrops and drowsiness. As part of our research program on natural compounds with biological activities, the objective of this study was to determine for the first time the chemical composition and biological activities of essential oils of Atractylis gummifera during beginning of the vegetative cycle (March), beginning of the flowering stage (April) and full bloom (May/June).

Methods: The essential oils were obtained by means of hydrodistillation and its components were analyzed using gas chromatography and mass spectrometry (GC/MS). The antioxidant properties were evaluated using two different methods i) Radical scavenging activity (DPPH) and ii) β-carotene bleaching assay. Whereas, the antifungal activity of the essential oils was investigated against five plant fungi. The fumigation toxicity of essential oils was evaluated against adults of Bactrocera oleae better known as the olive fly.

Results: The essential oil produced from the plant taken at the beginning of the vegetative cycle (March) had a high level of non-terpenic aliphatic compounds. On the other hand, the essential oil obtained during the period from the beginning of the flowering stage (April) showed that its proportion of non-terpene compounds decreased and that of sesquiterpene compounds increased. Finally, the essential oils obtained during the period from full bloom (May/June) consisted mainly of acetylene compounds such as carlina oxide and 13-methoxy carlina oxide. The results showed that essential oils from plants at full bloom presented interesting antioxidant and antifungal properties, while essential oil produced from plants at the beginning of the vegetative cycle (Mars) and at the beginning of the flowering stage (April) had better insecticidal activity.

Conclusion: The data presented here constitutes new findings in the field of the chemical characterization and biological potential of A. gummifera.

Keywords:

Atractylis gummifera, essential oil, biological activities, vegetative stages, gas chromatography, mass spectrometry.

Affiliation:

Laboratoire d’Ecologie et Gestion des Ecosystèmes Naturels, Université de Tlemcen, BP 119, 13000, Laboratoire of Organic Chemistry, Natural Substances and Analyses (COSNA), University of Tlemcen, Laboratoire des Substances Naturelles et Bioactives (LASNABIO), Université de Tlemcen, BP 119, 13000, Laboratoire des Substances Naturelles et Bioactives (LASNABIO), Université de Tlemcen, BP 119, 13000, Laboratoire of Organic Chemistry, Natural Substances and Analyses (COSNA), University of Tlemcen, Laboratoire des Substances Naturelles et Bioactives (LASNABIO), Université de Tlemcen, BP 119, 13000, Laboratoire d’Ecologie et Gestion des Ecosystèmes Naturels, Université de Tlemcen, BP 119, 13000, Laboratoire Chemistry of Natural Products, University of Corsica, CNRS UMR 6134, Campus Grimaldi, BP 52, 20250 Corte, Laboratoire Chemistry of Natural Products, University of Corsica, CNRS UMR 6134, Campus Grimaldi, BP 52, 20250 Corte



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