Faiza Ashfaq, Masood S.; Butt, Ahmad Bilal, Kanza A. Awan and Hafiz A. R. Suleria* Pages 521 - 527 ( 7 )
Background:The epidemiological transition is directly associated with dietary shift towards empty calories. In contrary, cabbage fights against oxidative stress mediated health disorders owing to the presence of nutritive constituents and low caloric count. The study aimed to assess the efficacy of red cabbage and its aqueous extract against renal and cardiac oxidative stress in response to hypercaloricdiet.Methods: Red cabbage and its aqueous extract were fed to normal rabbits (Study I) and hypercholes-terolemic diet (1% cholesterol) induced oxidatively stressed rabbits (Study II) for 12-weeks. Serum specific biomarkers of renal and cardiac oxidative stress including creatinine, urea, creatine kinase (CK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) were measured. Tissues of kidney and heart were employed to assess the activities of superoxide dismutase (SOD) and catalase (CAT) alongside; lipid peroxidation was also studied. Results: Red cabbage extract depicted more decrement (p<0.05) in serum creatinine and urea levels up to 14.45 and 9.01% in oxidatively stressed rabbits (Study II), respectively. In kidney tissues, red cab-bage extract showed an obvious reduction in lipid peroxidation up to24.07% in Study II that ultimately restored SOD (11.38%) and CAT (16.72%) activities. On the other hand, red cabbage demonstrated promising aptitude (p<0.05) in mitigating cardiac compromised condition by down-regulating lipid peroxidation by 16.44%, which considerably decreased the serum levels of CK, CK-MB, LDH andAST. Conclusion: Relatively, red cabbage extract showed a relatively better response in controlling renal oxidative stress as compared to red cabbage; however, vice-versa was observed in case of cardiac oxida-tive stress.
Red cabbage, Oxidative stress, Kidney, Heart, Normal rabbits, Hypercholesterolemic rabbits
National Institute of Food Science and Technology, Faculty of Food, Nutrition & Home Sciences, University of Agri-culture, Faisalabad, National Institute of Food Science and Technology, Faculty of Food, Nutrition & Home Sciences, University of Agri-culture, Faisalabad, University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, National Institute of Food Science and Technology, Faculty of Food, Nutrition & Home Sciences, University of Agri-culture, Faisalabad, UQ Diamantina Institute, Translational Research Institute, Faculty of Medicine, The University of Queensland, 37 Kent Street Woolloongabba, Brisbane, QLD 4102