Submit Manuscript  

Article Details


Sodium Valproate Affect Brain Antioxidant/Oxidant Status in Mice: Ameliorative Effect of Vitamin E and Chrysanthemum Fontanesii Extract

Author(s):

Amel Amrani*, Nassima Boubekri, Ouahiba Benaissa, Fadila Benayache, Samir Benayache and Djamila Zama   Pages 1 - 4 ( 4 )

Abstract:


Background: This study was aimed to evaluate the protective effects of n-butanol extract of Chrysanthemum fontanesii against oxidative stress induced by sodium valproate (VPA) in brain of female mice in comparison to vitamin E (Vit E).

Method: Mice were randomly divided into 5 groups (n: 8) and treated daily for 12 days. They received VPA (300 mg/kg i.p. injection), C. fontanesii buthanolic extract (100 mg/kg), and Vit E (100 mg/kg). Activities of antioxidant enzymes, total glutathione (GSH), and lipid peroxidation end products in brain were measured.

Results: Subacute exposure of mice to VPA resulted in a significant increase oxidative damage. Both C. fontanesii and Vit E at the dose of 100 mg/kg significantly reduced VPA-induced oxidative stress by inhibiting lipid peroxidation, increasing the content of glutathion, and restoring the activity of GPx.

Conclusion: It may be concluded that the phytoconstituents present in the n-butanol extract of aerial parts of C. fontanesii are responsible for the ameliorative effect of brain antioxidant/oxidant status affected by VPA.

Keywords:

Sodium valproate, Brain, Neurotoxicity, Oxidative Stress, Chrysanthemum fontanesii, Vitamin E

Affiliation:

Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives, Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, Route d`Aïn El Bey, 25000 Constantine, Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives, Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, Route d`Aïn El Bey, 25000 Constantine, Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives, Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, Route d`Aïn El Bey, 25000 Constantine, Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives, Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, Route d`Aïn El Bey, 25000 Constantine, Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives, Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, Route d`Aïn El Bey, 25000 Constantine, Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives, Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, Route d`Aïn El Bey, 25000 Constantine



Read Full-Text article