Vandana Garg and Rohit Dutt* Pages 4 - 12 ( 9 )
Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature.
Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects.
Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity.
Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases.
Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.
Fever, pyrexia, antipyretic plants, NSAIDS, antibiotics, flavivirus.
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, (HR) 124001, School of Medical and Allied Sciences, G. D. Goenka University, Gurugram 122103